| 2022-01-29 | 13:15 | CL Bulldogs/Zwolle CO 1 | RFC Haarlem CO 1 | Fanny Blankers-Koen Sportpark. ALMERE | 5 - 29 |
| 2022-02-12 | 12:30 | CL Bulldogs/Zwolle CO 1 | CL Zaandijk/West-Friesland CO 1 | Fanny Blankers-Koen Sportpark. ALMERE | 29 - 55 |
| 2022-02-12 | 13:30 | CL RRC/RC The Hookers CO 1 | HRC CO 2 | Sportcomplex Duivensteijn. ROTTERDAM | 14 - 19 |
| 2022-02-19 | 13:30 | CL Zaandijk/West-Friesland CO 1 | CL RRC/RC The Hookers CO 1 | De Blauwe Berg. HOORN | 0 - 24 |
| 2022-03-05 | 13:00 | RFC Haarlem CO 1 | CL RRC/RC The Hookers CO 1 | Van der Aart Sportpark. HAARLEM | 14 - 5 |
| 2022-03-05 | 13:00 | HRC CO 2 | CL Bulldogs/Zwolle CO 1 | Haagsche Rugby Club. DEN HAAG | 30 - 0 |
| 2022-03-10 | 19:30 | HRC CO 2 | RFC Haarlem CO 1 | Haagsche Rugby Club. DEN HAAG | 22 - 10 |
| 2022-03-12 | 13:00 | CL RRC/RC The Hookers CO 1 | CL Bulldogs/Zwolle CO 1 | Sportcomplex Duivensteijn. ROTTERDAM | 81 - 5 |
| 2022-03-12 | 13:15 | RFC Haarlem CO 1 | CL Zaandijk/West-Friesland CO 1 | Van der Aart Sportpark. HAARLEM | 26 - 15 |
| 2022-03-19 | 13:15 | RFC Haarlem CO 1 | CL Bulldogs/Zwolle CO 1 | Van der Aart Sportpark. HAARLEM | 47 - 14 |
| 2022-03-19 | 14:30 | HRC CO 2 | CL Zaandijk/West-Friesland CO 1 | Haagsche Rugby Club. DEN HAAG | 89 - 7 |
| 2022-03-26 | 12:00 | CL RRC/RC The Hookers CO 1 | RFC Haarlem CO 1 | HOEK VAN HOLLAND | 55 - 12 |
| 2022-03-26 | 13:00 | HRC CO 2 | CL Bulldogs/Zwolle CO 1 | Haagsche Rugby Club. DEN HAAG | 35 - 5 |
| 2022-04-02 | 14:00 | CL Zaandijk/West-Friesland CO 1 | CL Bulldogs/Zwolle CO 1 | SPORTPARK JAGERSVELD. ZAANDAM | 54 - 10 |
| 2022-04-02 | 14:30 | HRC CO 2 | CL RRC/RC The Hookers CO 1 | Haagsche Rugby Club. DEN HAAG | 17 - 23 |
| 2022-04-09 | 11:30 | RFC Haarlem CO 1 | HRC CO 2 | Van der Aart Sportpark. HAARLEM | 12 - 10 |
| 2022-04-09 | 13:00 | CL RRC/RC The Hookers CO 1 | CL Zaandijk/West-Friesland CO 1 | Sportcomplex Duivensteijn. ROTTERDAM | 30 - 0 |
| 2022-04-16 | 13:00 | CL Zaandijk/West-Friesland CO 1 | HRC CO 2 | SPORTPARK JAGERSVELD. ZAANDAM | 17 - 55 |
| 2022-04-23 | 12:00 | CL Bulldogs/Zwolle CO 1 | CL RRC/RC The Hookers CO 1 | Fanny Blankers-Koen Sportpark. ALMERE | 17 - 39 |
| 2022-04-23 | 13:00 | CL Zaandijk/West-Friesland CO 1 | RFC Haarlem CO 1 | De Blauwe Berg. HOORN | 14 - 39 |