| 2021-11-06 | 13:00 | RC The Dukes CO 1 | BRC CO 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 18 - 20 |
| 2021-11-06 | 13:15 | CL CaWa Rugby CO 1 | HRC CO 1 | Sportpark Wouterland. CASTRICUM | 0 - 31 |
| 2021-11-13 | 13:00 | BRC CO 1 | CL CaWa Rugby CO 1 | Sportboulevard Wisselaar. BREDA | 15 - 17 |
| 2021-11-13 | 14:00 | URC CO 1 | RC The Dukes CO 1 | Sportpark Rijnvliet. UTRECHT | 38 - 10 |
| 2021-11-13 | 14:30 | HRC CO 1 | RC 't Gooi CO 1 | Haagsche Rugby Club. DEN HAAG | 29 - 0 |
| 2021-11-20 | 13:00 | CL CaWa Rugby CO 1 | RC 't Gooi CO 1 | Sportpark Wouterland. CASTRICUM | 35 - 10 |
| 2021-11-20 | 13:00 | RC The Dukes CO 1 | HRC CO 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 8 - 31 |
| 2021-11-20 | 13:00 | BRC CO 1 | URC CO 1 | Sportboulevard Wisselaar. BREDA | 3 - 43 |
| 2021-11-25 | 19:30 | RC 't Gooi CO 1 | URC CO 1 | Sportpark. NAARDEN | 5 - 52 |
| 2021-12-11 | 13:00 | RC 't Gooi CO 1 | RC The Dukes CO 1 | Sportpark. NAARDEN | afgelast |
| 2021-12-11 | 13:00 | CL CaWa Rugby CO 1 | URC CO 1 | Sportpark Wouterland. CASTRICUM | afgelast |
| 2021-12-11 | 14:30 | HRC CO 1 | BRC CO 1 | Haagsche Rugby Club. DEN HAAG | afgelast |
| 2021-12-18 | 13:00 | RC The Dukes CO 1 | CL CaWa Rugby CO 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | afgelast |
| 2021-12-18 | 13:00 | URC CO 1 | HRC CO 1 | Sportpark Rijnvliet. UTRECHT | afgelast |
| 2021-12-18 | 13:30 | BRC CO 1 | RC 't Gooi CO 1 | Sportboulevard Wisselaar. BREDA | afgelast |