| 2021-11-13 | 13:00 | CL Twente CO 1 | CL Noord CO 1 | Sportpark Keizerslanden. DEVENTER | 55 - 23 |
| 2021-11-13 | 14:00 | CL Hawks/Houtsche CO 1 | CL Noord West CO 1 | Rugbyclub Haarlemmermeer Hawks. Nieuw Vennep | 54 - 25 |
| 2021-11-20 | 13:00 | CL Noord CO 1 | CL Hawks/Houtsche CO 1 | Sportpark De Hulsebosch. DWINGELOO | 10 - 27 |
| 2021-11-27 | 14:15 | CL Noord West CO 1 | CL Twente CO 1 | RFC Haarlem, Haarlem | 0 - 64 |
| 2021-12-11 | 13:00 | CL Hawks/Houtsche CO 1 | CL Twente CO 1 | Rugbyclub Haarlemmermeer Hawks. Nieuw Vennep | afgelast |
| 2021-12-11 | 13:00 | CL Noord West CO 1 | CL Noord CO 1 | Sportpark "De Linie". DEN HELDER | afgelast |
| 2021-12-18 | 13:00 | CL Twente CO 1 | CL Hawks/Houtsche CO 1 | Sportpark de Thij. Oldenzaal | afgelast |
| 2021-12-18 | 13:00 | CL Noord CO 1 | CL Noord West CO 1 | Evenemententerrein | afgelast |