| 2022-02-05 | 12:00 | CL Noord CO 1 | CL Twente CO 1 | Evenemententerrein. HAVELTE | 17 - 64 |
| 2022-02-05 | 13:00 | CL Noord West CO 1 | CL Hawks/Houtsche CO 1 | Sportpark "De Linie". DEN HELDER | 22 - 26 |
| 2022-02-12 | 13:00 | CL Hawks/Houtsche CO 1 | CL Noord CO 1 | Rugbyclub Haarlemmermeer Hawks. Nieuw Vennep | 30 - 0 |
| 2022-02-12 | 13:00 | CL Twente CO 1 | RC The Bassets CO 1 | Wethouder Horstman Sportpark. ENSCHEDE | 31 - 38 |
| 2022-02-19 | 13:00 | RC The Bassets CO 1 | CL Hawks/Houtsche CO 1 | SASSENHEIM | 81 - 17 |
| 2022-02-19 | 13:30 | CL Noord CO 1 | CL Noord West CO 1 | Sportpark Buitenbaan. HEERENVEEN | 67 - 21 |
| 2022-02-26 | 13:00 | RC The Bassets CO 1 | CL Noord CO 1 | SASSENHEIM | 0 - 30 |
| 2022-02-26 | 13:00 | CL Noord West CO 1 | CL Twente CO 1 | Fanny Blankers-Koen Sportpark. ALMERE | 17 - 44 |
| 2022-03-12 | 12:30 | CL Noord West CO 1 | RC The Bassets CO 1 | Van der Aart Sportpark. HAARLEM | 12 - 78 |
| 2022-03-12 | 13:00 | CL Hawks/Houtsche CO 1 | CL Twente CO 1 | Rugbyclub Haarlemmermeer Hawks. Nieuw Vennep | 29 - 44 |
| 2022-03-19 | 13:00 | CL Noord CO 1 | RC The Bassets CO 1 | Sportpark Meerdijk. EMMEN | 30 - 0 |
| 2022-03-19 | 13:00 | CL Twente CO 1 | CL Noord West CO 1 | Fanny Blankers-Koen Sportpark. ALMERE | 12 - 26 |
| 2022-03-26 | 13:00 | CL Twente CO 1 | CL Noord CO 1 | Marialust. APELDOORN | 72 - 3 |
| 2022-04-02 | 13:00 | CL Noord CO 1 | CL Hawks/Houtsche CO 1 | Evenemententerrein. HAVELTE | 45 - 45 |
| 2022-04-02 | 13:00 | RC The Bassets CO 1 | CL Twente CO 1 | SASSENHEIM | 30 - 0 |
| 2022-04-09 | 10:00 | CL Noord West CO 1 | CL Noord CO 1 | Sportpark "De Linie". DEN HELDER | 58 - 55 |
| 2022-04-09 | 13:00 | CL Hawks/Houtsche CO 1 | RC The Bassets CO 1 | Rugbyclub Haarlemmermeer Hawks. Nieuw Vennep | 5 - 37 |
| 2022-04-13 | 19:30 | CL Hawks/Houtsche CO 1 | CL Noord West CO 1 | Rugbyclub Haarlemmermeer Hawks. Nieuw Vennep | 30 - 0 |
| 2022-04-23 | 12:30 | RC The Bassets CO 1 | CL Noord West CO 1 | SASSENHEIM | 83 - 27 |
| 2022-04-23 | 13:30 | CL Twente CO 1 | CL Hawks/Houtsche CO 1 | Sportpark Keizerslanden. DEVENTER | 43 - 19 |