| 2022-01-29 | 13:30 | CL BRC/Dukes/Tilburg CO 2 | HRC CO 3 | Sportboulevard Wisselaar. BREDA | 40 - 0 |
| 2022-02-05 | 13:00 | CL Eindhoven/Bokkerijders CO 1 | CL RC Delft/Hermes/Sparta CO 1 | Sportpark Eindhoven Noord. EINDHOVEN | 34 - 19 |
| 2022-02-05 | 14:30 | HRC CO 3 | CL River Colts CO 1 | Haagsche Rugby Club. DEN HAAG | 41 - 39 |
| 2022-02-12 | 10:30 | CL River Colts CO 1 | CL BRC/Dukes/Tilburg CO 2 | Sportpark Rauwenhof. TIEL | 27 - 22 |
| 2022-02-19 | 13:30 | CL BRC/Dukes/Tilburg CO 2 | CL RC Delft/Hermes/Sparta CO 1 | Sportpark Vredelust-Heidepark. TILBURG | 15 - 14 |
| 2022-03-05 | 11:00 | CL River Colts CO 1 | CL Eindhoven/Bokkerijders CO 1 | Sportpark Rauwenhof. TIEL | 30 - 0 |
| 2022-03-12 | 13:00 | CL Eindhoven/Bokkerijders CO 1 | CL BRC/Dukes/Tilburg CO 2 | Sportpark Kitskensberg. ROERMOND | 20 - 53 |
| 2022-03-12 | 13:00 | CL RC Delft/Hermes/Sparta CO 1 | CL River Colts CO 1 | Sportpark Biesland. Delft | 29 - 38 |
| 2022-03-19 | 10:30 | CL River Colts CO 1 | CL Eindhoven/Bokkerijders CO 1 | Sportpark Rauwenhof. TIEL | 29 - 5 |
| 2022-03-19 | 13:00 | HRC CO 3 | CL BRC/Dukes/Tilburg CO 2 | Haagsche Rugby Club. DEN HAAG | 12 - 51 |
| 2022-03-24 | 19:00 | CL RC Delft/Hermes/Sparta CO 1 | HRC CO 3 | Sportpark Biesland. Delft | 27 - 38 |
| 2022-03-26 | 13:30 | CL River Colts CO 1 | HRC CO 3 | Sportpark Galecop 4, Nieuwegein | 78 - 14 |
| 2022-03-26 | 14:15 | CL RC Delft/Hermes/Sparta CO 1 | CL Eindhoven/Bokkerijders CO 1 | Sportpark Biesland. Delft | 20 - 52 |
| 2022-04-02 | 13:00 | HRC CO 3 | CL RC Delft/Hermes/Sparta CO 1 | Haagsche Rugby Club. DEN HAAG | 0 - 53 |
| 2022-04-02 | 13:15 | CL BRC/Dukes/Tilburg CO 2 | CL River Colts CO 1 | Sportpark Vredelust-Heidepark. TILBURG | 17 - 106 |
| 2022-04-09 | 13:00 | CL Eindhoven/Bokkerijders CO 1 | HRC CO 3 | Sportpark Kitskensberg. ROERMOND | 30 - 0 |
| 2022-04-09 | 14:00 | CL RC Delft/Hermes/Sparta CO 1 | CL BRC/Dukes/Tilburg CO 2 | Sportpark Biesland. Delft | 30 - 0 |
| 2022-04-16 | 13:00 | HRC CO 3 | CL Eindhoven/Bokkerijders CO 1 | Haagsche Rugby Club. DEN HAAG | 30 - 0 |
| 2022-04-23 | 13:00 | CL BRC/Dukes/Tilburg CO 2 | CL Eindhoven/Bokkerijders CO 1 | Sportboulevard Wisselaar. BREDA | 30 - 0 |
| 2022-04-23 | 13:30 | CL River Colts CO 1 | CL RC Delft/Hermes/Sparta CO 1 | Bemmel, Drieske 5 | 107 - 5 |