| 2022-01-29 | 11:00 | RC Hilversum CU 1 | CL RCW/Zaandijk CU 1 | Sportpark Berestein. Hilversum | 26 - 36 |
| 2022-01-29 | 12:00 | RC Bulldogs CU 1 | Cas RC CU 1 | Fanny Blankers-Koen Sportpark. ALMERE | 20 - 24 |
| 2022-02-05 | 10:30 | CL RCW/Zaandijk CU 1 | RC Bulldogs CU 1 | SPORTPARK JAGERSVELD. ZAANDAM | 52 - 0 |
| 2022-02-05 | 11:00 | Cas RC CU 1 | CL Twente CU 1 | Sportpark Wouterland. CASTRICUM | 17 - 41 |
| 2022-02-05 | 12:00 | RC Eemland CU 1 | RC Hilversum CU 1 | Sportpark De Bokkeduinen. AMERSFOORT | 31 - 15 |
| 2022-02-12 | 11:00 | RC Bulldogs CU 1 | RC Hilversum CU 1 | Fanny Blankers-Koen Sportpark. ALMERE | 20 - 35 |
| 2022-02-12 | 11:00 | CL Twente CU 1 | CL RCW/Zaandijk CU 1 | Wethouder Horstman Sportpark. ENSCHEDE | 45 - 0 |
| 2022-02-19 | 11:00 | CL RCW/Zaandijk CU 1 | Cas RC CU 1 | PURMEREND | 24 - 40 |
| 2022-02-19 | 13:00 | RC Eemland CU 1 | RC Bulldogs CU 1 | Barchman Wuytierslaan 95, 3819 AB Amersfoort | 36 - 22 |
| 2022-02-26 | 11:00 | RC Hilversum CU 1 | CL Twente CU 1 | Sportpark Berestein. Hilversum | 7 - 52 |
| 2022-03-05 | 11:00 | Cas RC CU 1 | RC Eemland CU 1 | Sportpark Wouterland. CASTRICUM | 21 - 26 |
| 2022-03-12 | 10:30 | Cas RC CU 1 | RC Hilversum CU 1 | Sportpark Wouterland. CASTRICUM | 43 - 24 |
| 2022-03-12 | 11:00 | CL Twente CU 1 | RC Bulldogs CU 1 | Sportpark de Thij. Oldenzaal | 45 - 0 |
| 2022-03-12 | 12:00 | RC Eemland CU 1 | CL RCW/Zaandijk CU 1 | Sportpark De Bokkeduinen. AMERSFOORT | 51 - 7 |
| 2022-03-19 | 11:00 | CL RCW/Zaandijk CU 1 | RC Hilversum CU 1 | PURMEREND | 54 - 0 |
| 2022-03-19 | 11:00 | Cas RC CU 1 | RC Bulldogs CU 1 | Sportpark Wouterland. CASTRICUM | 14 - 17 |
| 2022-03-19 | 12:15 | RC Eemland CU 1 | CL Twente CU 1 | Sportpark De Bokkeduinen. AMERSFOORT | 21 - 34 |
| 2022-03-26 | 11:00 | RC Bulldogs CU 1 | CL RCW/Zaandijk CU 1 | Fanny Blankers-Koen Sportpark. ALMERE | 40 - 28 |
| 2022-03-26 | 11:00 | RC Hilversum CU 1 | RC Eemland CU 1 | Sportpark Berestein. Hilversum | 10 - 50 |
| 2022-03-26 | 11:00 | CL Twente CU 1 | Cas RC CU 1 | Het Wendelgoor. Almelo | 43 - 10 |
| 2022-04-02 | 11:00 | RC Hilversum CU 1 | RC Bulldogs CU 1 | Sportpark Berestein. Hilversum | 26 - 42 |
| 2022-04-02 | 11:00 | CL RCW/Zaandijk CU 1 | CL Twente CU 1 | PURMEREND | 5 - 50 |
| 2022-04-02 | 14:00 | RC Eemland CU 1 | Cas RC CU 1 | Sportpark De Bokkeduinen. AMERSFOORT | 30 - 0 |
| 2022-04-09 | 11:00 | CL Twente CU 1 | RC Hilversum CU 1 | Sportpark Veldwijk. HENGELO OV | 45 - 0 |
| 2022-04-09 | 11:00 | Cas RC CU 1 | CL RCW/Zaandijk CU 1 | SPORTPARK JAGERSVELD. ZAANDAM | 15 - 31 |
| 2022-04-09 | 11:00 | RC Bulldogs CU 1 | RC Eemland CU 1 | Fanny Blankers-Koen Sportpark. ALMERE | 32 - 21 |
| 2022-04-16 | 11:00 | CL Twente CU 1 | RC Eemland CU 1 | Wethouder Horstman Sportpark. ENSCHEDE | 43 - 0 |
| 2022-04-23 | 10:00 | RC Bulldogs CU 1 | CL Twente CU 1 | Fanny Blankers-Koen Sportpark. ALMERE | 48 - 24 |
| 2022-04-23 | 11:00 | RC Hilversum CU 1 | Cas RC CU 1 | Sportpark Berestein. Hilversum | 5 - 50 |
| 2022-04-23 | 11:00 | CL RCW/Zaandijk CU 1 | RC Eemland CU 1 | PURMEREND | 30 - 0 |