| 2021-11-06 | 12:00 | The Wasps CU 1 | RC Groningen CU 1 | De Biezen. Nijmegen | 0 - 38 |
| 2021-11-06 | 12:30 | URC CU 1 | RC The Pink Panthers CU 1 | Sportpark Rijnvliet. UTRECHT | 80 - 0 |
| 2021-11-13 | 11:00 | RC The Pink Panthers CU 1 | RC 't Gooi CU 1 | De Woerd. DRIEBERGEN | 24 - 29 |
| 2021-11-13 | 11:00 | The Pickwick Players CU 1 | The Wasps CU 1 | Sportpark Keizerslanden. DEVENTER | 38 - 17 |
| 2021-11-13 | 11:00 | RC Groningen CU 1 | URC CU 1 | Esserberg. HAREN | 5 - 24 |
| 2021-11-20 | 11:00 | The Wasps CU 1 | RC The Pink Panthers CU 1 | De Biezen. Nijmegen | 10 - 31 |
| 2021-11-20 | 11:15 | RC Groningen CU 1 | The Pickwick Players CU 1 | Esserberg. HAREN | 22 - 33 |
| 2021-11-20 | 12:00 | URC CU 1 | RC 't Gooi CU 1 | Sportpark Rijnvliet. UTRECHT | 40 - 5 |
| 2021-11-27 | 11:00 | RC 't Gooi CU 1 | The Pickwick Players CU 1 | Sportpark. NAARDEN | |
| 2021-12-11 | 11:00 | RC The Pink Panthers CU 1 | RC Groningen CU 1 | De Woerd. DRIEBERGEN | afgelast |
| 2021-12-11 | 11:00 | RC 't Gooi CU 1 | The Wasps CU 1 | Sportpark. NAARDEN | afgelast |
| 2021-12-11 | 11:00 | URC CU 1 | The Pickwick Players CU 1 | Sportpark Rijnvliet. UTRECHT | afgelast |
| 2021-12-18 | 11:00 | The Pickwick Players CU 1 | RC The Pink Panthers CU 1 | Sportpark Keizerslanden. DEVENTER | afgelast |
| 2021-12-18 | 11:00 | The Wasps CU 1 | URC CU 1 | Moleneind. Uden | afgelast |
| 2021-12-18 | 11:15 | RC Groningen CU 1 | RC 't Gooi CU 1 | Esserberg. HAREN | afgelast |