| 2022-01-29 | 11:00 | RC The Pink Panthers CU 1 | RC Delft CU 1 | De Woerd. DRIEBERGEN | 7 - 31 |
| 2022-01-29 | 11:00 | The Pickwick Players CU 1 | CL Waterweg Warriors CU 1 | Sportpark Keizerslanden. DEVENTER | 10 - 38 |
| 2022-01-29 | 11:15 | RC Groningen CU 1 | The Wasps CU 1 | Esserberg. HAREN | 38 - 7 |
| 2022-02-05 | 11:00 | The Wasps CU 1 | The Pickwick Players CU 1 | De Biezen. Nijmegen | 55 - 17 |
| 2022-02-05 | 12:00 | RC Delft CU 1 | RC Groningen CU 1 | Sportpark Biesland. Delft | 40 - 29 |
| 2022-02-12 | 12:00 | RC The Pink Panthers CU 1 | The Wasps CU 1 | De Woerd. DRIEBERGEN | 12 - 27 |
| 2022-02-12 | 12:00 | The Pickwick Players CU 1 | RC Groningen CU 1 | Sportpark Keizerslanden. DEVENTER | 0 - 48 |
| 2022-02-12 | 12:30 | CL Waterweg Warriors CU 1 | RC Delft CU 1 | Hermes Rugby, Trimpad 12, 3118 JJ Schiedam | 10 - 5 |
| 2022-02-19 | 11:00 | The Pickwick Players CU 1 | RC Delft CU 1 | Sportpark Keizerslanden. DEVENTER | 10 - 52 |
| 2022-02-19 | 11:15 | RC Groningen CU 1 | RC The Pink Panthers CU 1 | Esserberg. HAREN | 64 - 31 |
| 2022-02-19 | 12:00 | The Wasps CU 1 | CL Waterweg Warriors CU 1 | Moleneind. Uden | 19 - 17 |
| 2022-02-26 | 11:00 | CL Waterweg Warriors CU 1 | RC The Pink Panthers CU 1 | HOEK VAN HOLLAND | 36 - 7 |
| 2022-03-12 | 12:00 | RC Delft CU 1 | The Wasps CU 1 | Sportpark Biesland. Delft | 17 - 14 |
| 2022-03-12 | 12:00 | RC The Pink Panthers CU 1 | The Pickwick Players CU 1 | De Woerd. DRIEBERGEN | 52 - 38 |
| 2022-03-12 | 12:30 | CL Waterweg Warriors CU 1 | RC Groningen CU 1 | Hermes Rugby, Trimpad 12, 3118 JJ Schiedam | 17 - 53 |
| 2022-03-19 | 11:00 | RC Delft CU 1 | RC The Pink Panthers CU 1 | Sportpark Biesland. Delft | 39 - 12 |
| 2022-03-19 | 12:15 | The Wasps CU 1 | RC Groningen CU 1 | De Biezen. Nijmegen | 17 - 17 |
| 2022-03-19 | 13:00 | CL Waterweg Warriors CU 1 | The Pickwick Players CU 1 | HOEK VAN HOLLAND | 26 - 39 |
| 2022-03-26 | 11:00 | The Pickwick Players CU 1 | The Wasps CU 1 | Sportpark Keizerslanden. DEVENTER | 33 - 28 |
| 2022-03-26 | 11:00 | RC The Pink Panthers CU 1 | CL Waterweg Warriors CU 1 | De Woerd. DRIEBERGEN | 40 - 31 |
| 2022-03-26 | 12:15 | RC Groningen CU 1 | RC Delft CU 1 | Esserberg. HAREN | 29 - 29 |
| 2022-04-02 | 11:00 | The Wasps CU 1 | RC The Pink Panthers CU 1 | De Biezen. Nijmegen | 26 - 19 |
| 2022-04-02 | 11:15 | RC Groningen CU 1 | The Pickwick Players CU 1 | Esserberg. HAREN | 69 - 22 |
| 2022-04-02 | 13:00 | RC Delft CU 1 | CL Waterweg Warriors CU 1 | Sportpark Biesland. Delft | 43 - 5 |
| 2022-04-09 | 11:00 | RC The Pink Panthers CU 1 | RC Groningen CU 1 | De Woerd. DRIEBERGEN | 21 - 29 |
| 2022-04-09 | 12:00 | CL Waterweg Warriors CU 1 | The Wasps CU 1 | HOEK VAN HOLLAND | 34 - 26 |
| 2022-04-09 | 13:00 | RC Delft CU 1 | The Pickwick Players CU 1 | Sportpark Biesland. Delft | 19 - 10 |
| 2022-04-23 | 12:00 | RC Groningen CU 1 | CL Waterweg Warriors CU 1 | Esserberg. HAREN | 29 - 22 |
| 2022-04-23 | 12:00 | The Pickwick Players CU 1 | RC The Pink Panthers CU 1 | Sportpark Keizerslanden. DEVENTER | 53 - 7 |
| 2022-04-23 | 12:15 | The Wasps CU 1 | RC Delft CU 1 | Moleneind. Uden | 12 - 24 |