| 2021-11-06 | 10:00 | CL Alkmaar/West-Friesland CU 1 | RC DIOK CU 2 | De Blauwe Berg. HOORN | 10 - 32 |
| 2021-11-06 | 11:00 | CL Haarlem/Smugglers CU 2 | RC The Bassets CU 1 | Van der Aart Sportpark. HAARLEM | 39 - 15 |
| 2021-11-06 | 11:00 | CL RC Den Helder/Rush CU 1 | HRC CU 3 | Sportpark "De Linie". DEN HELDER | 0 - 41 |
| 2021-11-13 | 11:00 | RC The Bassets CU 1 | CL RC Den Helder/Rush CU 1 | SASSENHEIM | 17 - 40 |
| 2021-11-13 | 11:00 | RC DIOK CU 2 | CL Haarlem/Smugglers CU 2 | RC DIOK. LEIDEN | 12 - 17 |
| 2021-11-13 | 12:00 | HRC CU 3 | CL Alkmaar/West-Friesland CU 1 | Haagsche Rugby Club. DEN HAAG | 22 - 21 |
| 2021-11-20 | 11:00 | RC The Bassets CU 1 | RC DIOK CU 2 | SASSENHEIM | 0 - 46 |
| 2021-11-20 | 11:00 | CL RC Den Helder/Rush CU 1 | CL Alkmaar/West-Friesland CU 1 | Sportpark "De Linie". DEN HELDER | 12 - 22 |
| 2021-11-27 | 13:00 | CL Haarlem/Smugglers CU 2 | HRC CU 3 | Van der Aart Sportpark. HAARLEM | 22 - 19 |
| 2021-12-11 | 11:00 | CL RC Den Helder/Rush CU 1 | RC DIOK CU 2 | Sportpark "De Linie". DEN HELDER | afgelast |
| 2021-12-11 | 12:00 | HRC CU 3 | RC The Bassets CU 1 | Haagsche Rugby Club. DEN HAAG | afgelast |
| 2021-12-11 | 12:00 | CL Alkmaar/West-Friesland CU 1 | CL Haarlem/Smugglers CU 2 | Sportpark Robonsbosweg. ALKMAAR | afgelast |
| 2021-12-18 | 11:00 | RC DIOK CU 2 | HRC CU 3 | RC DIOK. LEIDEN | afgelast |
| 2021-12-18 | 11:00 | RC The Bassets CU 1 | CL Alkmaar/West-Friesland CU 1 | SASSENHEIM | afgelast |
| 2021-12-18 | 11:00 | CL Haarlem/Smugglers CU 2 | CL RC Den Helder/Rush CU 1 | Van der Aart Sportpark. HAARLEM | afgelast |