| 2022-01-29 | 11:00 | CL Eindhoven/Bokkerijders CU 1 | Maastrichtse RC CU 1 | Sportpark Eindhoven Noord. EINDHOVEN | 57 - 24 |
| 2022-01-29 | 11:00 | CL Wild Pigs CU 1 | CL Paarse Duivels CU 1 | Sportpark de Bezelhorst. DOETINCHEM | 45 - 7 |
| 2022-02-05 | 11:00 | CL Vets/Oysters/Ducks CU 1 | CL Wild Pigs CU 1 | Sportpark Den Dries. VALKENSWAARD | 49 - 17 |
| 2022-02-05 | 11:00 | CL Paarse Duivels CU 1 | CL Eindhoven/Bokkerijders CU 1 | Sportpark De Zoom. WAGENINGEN | 0 - 30 |
| 2022-02-05 | 11:00 | Maastrichtse RC CU 1 | RC The Dukes CU 2 | Sportpark West. MAASTRICHT | 42 - 37 |
| 2022-02-12 | 11:00 | CL Eindhoven/Bokkerijders CU 1 | CL Vets/Oysters/Ducks CU 1 | Sportpark Eindhoven Noord. EINDHOVEN | 45 - 0 |
| 2022-02-12 | 11:00 | CL Paarse Duivels CU 1 | Maastrichtse RC CU 1 | Sportpark Hengelder. ZEVENAAR | 10 - 53 |
| 2022-02-12 | 11:00 | CL Wild Pigs CU 1 | RC The Dukes CU 2 | Sportpark De Bakenhof. ARNHEM | 34 - 10 |
| 2022-02-19 | 11:00 | CL Vets/Oysters/Ducks CU 1 | CL Paarse Duivels CU 1 | Den Wielakker. BOXTEL | 64 - 12 |
| 2022-02-19 | 11:00 | CL Wild Pigs CU 1 | Maastrichtse RC CU 1 | Sportpark De Bakenhof. ARNHEM | 55 - 7 |
| 2022-02-19 | 12:00 | RC The Dukes CU 2 | CL Eindhoven/Bokkerijders CU 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 42 - 35 |
| 2022-02-26 | 12:30 | RC The Dukes CU 2 | CL Vets/Oysters/Ducks CU 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 41 - 22 |
| 2022-03-12 | 11:00 | CL Paarse Duivels CU 1 | RC The Dukes CU 2 | Sportpark Hengelder. ZEVENAAR | 27 - 33 |
| 2022-03-12 | 11:00 | CL Eindhoven/Bokkerijders CU 1 | CL Wild Pigs CU 1 | Sportpark Kitskensberg. ROERMOND | 40 - 28 |
| 2022-03-12 | 11:00 | Maastrichtse RC CU 1 | CL Vets/Oysters/Ducks CU 1 | Sportpark West. MAASTRICHT | 29 - 46 |
| 2022-03-19 | 10:00 | CL Paarse Duivels CU 1 | CL Wild Pigs CU 1 | Sportpark De Zoom. WAGENINGEN | 10 - 31 |
| 2022-03-19 | 11:00 | CL Vets/Oysters/Ducks CU 1 | RC The Dukes CU 2 | Sportpark Den Dries. VALKENSWAARD | 38 - 55 |
| 2022-03-19 | 11:00 | Maastrichtse RC CU 1 | CL Eindhoven/Bokkerijders CU 1 | Sportpark West. MAASTRICHT | 20 - 40 |
| 2022-03-26 | 11:00 | RC The Dukes CU 2 | Maastrichtse RC CU 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 22 - 38 |
| 2022-03-26 | 11:00 | CL Wild Pigs CU 1 | CL Vets/Oysters/Ducks CU 1 | Sportpark de Bezelhorst. DOETINCHEM | 58 - 7 |
| 2022-03-26 | 11:00 | CL Eindhoven/Bokkerijders CU 1 | CL Paarse Duivels CU 1 | Sportpark Eindhoven Noord. EINDHOVEN | 52 - 12 |
| 2022-04-02 | 11:00 | Maastrichtse RC CU 1 | CL Paarse Duivels CU 1 | Sportpark West. MAASTRICHT | |
| 2022-04-02 | 12:00 | RC The Dukes CU 2 | CL Wild Pigs CU 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 37 - 28 |
| 2022-04-02 | 13:30 | CL Vets/Oysters/Ducks CU 1 | CL Eindhoven/Bokkerijders CU 1 | Sportpark Den Dries. VALKENSWAARD | 33 - 19 |
| 2022-04-09 | 11:00 | CL Paarse Duivels CU 1 | CL Vets/Oysters/Ducks CU 1 | Sportpark De Zoom. WAGENINGEN | 5 - 43 |
| 2022-04-09 | 11:00 | CL Eindhoven/Bokkerijders CU 1 | RC The Dukes CU 2 | Sportpark Kitskensberg. ROERMOND | 45 - 0 |
| 2022-04-09 | 11:00 | Maastrichtse RC CU 1 | CL Wild Pigs CU 1 | Sportpark West. MAASTRICHT | 22 - 24 |
| 2022-04-23 | 11:00 | CL Vets/Oysters/Ducks CU 1 | Maastrichtse RC CU 1 | Sportpark Den Dries. VALKENSWAARD | 52 - 33 |
| 2022-04-23 | 11:00 | CL Wild Pigs CU 1 | CL Eindhoven/Bokkerijders CU 1 | Sportpark De Bakenhof. ARNHEM | 7 - 27 |
| 2022-04-23 | 11:30 | RC The Dukes CU 2 | CL Paarse Duivels CU 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 33 - 19 |