| 2022-02-20 | 13:00 | RC Tilburg D1 | Lady Wasps D1 | Sportpark Vredelust-Heidepark. TILBURG | 17 - 7 |
| 2022-03-06 | 13:00 | Lady Wasps D1 | Bredase RC D1 | De Biezen. Nijmegen | 40 - 17 |
| 2022-03-06 | 13:30 | CL Zwolle/Dwingeloo D1 | RC Tilburg D1 | Sportpark De Marslanden. ZWOLLE | 17 - 19 |
| 2022-03-06 | 15:00 | RC DIOK D1 | Cas RC Ladies D1 | RC DIOK. LEIDEN | 0 - 30 |
| 2022-03-13 | 13:00 | RC DIOK D1 | CL Zwolle/Dwingeloo D1 | RC DIOK. LEIDEN | 84 - 0 |
| 2022-03-13 | 13:00 | Bredase RC D1 | RC Tilburg D1 | Sportboulevard Wisselaar. BREDA | 43 - 24 |
| 2022-03-13 | 15:00 | Cas RC Ladies D1 | Lady Wasps D1 | Sportpark Wouterland. CASTRICUM | 48 - 8 |
| 2022-03-20 | 13:00 | RC Tilburg D1 | Cas RC Ladies D1 | Sportpark Vredelust-Heidepark. TILBURG | 10 - 43 |
| 2022-03-20 | 15:00 | Bredase RC D1 | CL Zwolle/Dwingeloo D1 | Sportboulevard Wisselaar. BREDA | 44 - 7 |
| 2022-03-27 | 13:00 | Cas RC Ladies D1 | CL Zwolle/Dwingeloo D1 | Sportpark Wouterland. CASTRICUM | 79 - 0 |
| 2022-03-27 | 13:00 | Bredase RC D1 | RC DIOK D1 | Sportboulevard Wisselaar. BREDA | 15 - 29 |
| 2022-04-03 | 13:30 | CL Zwolle/Dwingeloo D1 | Lady Wasps D1 | Sportpark De Marslanden. ZWOLLE | 48 - 7 |
| 2022-04-03 | 15:00 | RC DIOK D1 | RC Tilburg D1 | RC DIOK. LEIDEN | 73 - 5 |
| 2022-04-10 | 13:00 | Lady Wasps D1 | RC Tilburg D1 | De Biezen. Nijmegen | 41 - 24 |
| 2022-04-10 | 13:00 | RC DIOK D1 | Bredase RC D1 | RC DIOK. LEIDEN | 95 - 17 |
| 2022-04-10 | 14:30 | CL Zwolle/Dwingeloo D1 | Cas RC Ladies D1 | Sportpark De Hulsebosch. DWINGELOO | 7 - 48 |
| 2022-04-24 | 11:30 | RC Tilburg D1 | CL Zwolle/Dwingeloo D1 | Sportpark Vredelust-Heidepark. TILBURG | 109 - 5 |
| 2022-04-24 | 15:00 | Cas RC Ladies D1 | RC DIOK D1 | Sportpark Wouterland. CASTRICUM | 7 - 34 |
| 2022-04-24 | 15:00 | Bredase RC D1 | Lady Wasps D1 | Sportboulevard Wisselaar. BREDA | 15 - 10 |
| 2022-05-01 | 13:00 | Lady Wasps D1 | RC DIOK D1 | De Biezen. Nijmegen | 17 - 45 |
| 2022-05-01 | 15:00 | Cas RC Ladies D1 | Bredase RC D1 | Sportpark Wouterland. CASTRICUM | 19 - 29 |
| 2022-05-15 | 13:00 | RC Tilburg D1 | Bredase RC D1 | Sportpark Vredelust-Heidepark. TILBURG | 22 - 15 |
| 2022-05-15 | 13:00 | Lady Wasps D1 | Cas RC Ladies D1 | De Biezen. Nijmegen | 28 - 19 |
| 2022-05-15 | 14:30 | CL Zwolle/Dwingeloo D1 | RC DIOK D1 | Evenemententerrein. HAVELTE | 0 - 78 |
| 2022-05-22 | 13:00 | Cas RC Ladies D1 | RC Tilburg D1 | Sportpark Wouterland. CASTRICUM | 0 - 30 |
| 2022-05-22 | 13:30 | RC DIOK D1 | Lady Wasps D1 | RC DIOK. LEIDEN | 51 - 40 |
| 2022-05-22 | 14:30 | CL Zwolle/Dwingeloo D1 | Bredase RC D1 | Sportpark De Hulsebosch. DWINGELOO | 0 - 47 |
| 2022-05-29 | 13:00 | Lady Wasps D1 | CL Zwolle/Dwingeloo D1 | De Biezen. Nijmegen | 30 - 0 |
| 2022-05-29 | 13:00 | RC Tilburg D1 | RC DIOK D1 | Sportpark Vredelust-Heidepark. TILBURG | 26 - 43 |
| 2022-05-29 | 13:00 | Bredase RC D1 | Cas RC Ladies D1 | Sportboulevard Wisselaar. BREDA | 24 - 7 |