| 2022-02-20 | 14:30 | RC The Bassets 2 | The Pickwick Players 1 | SASSENHEIM | 31 - 29 |
| 2022-02-20 | 15:00 | RC The Dukes Espoirs | URC 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 30 - 0 |
| 2022-02-20 | 15:00 | RC Hilversum 2 | RC Eemland 2 | Sportpark Berestein. Hilversum | 15 - 0 |
| 2022-03-06 | 14:30 | URC 2 | RC Hilversum 2 | Sportpark Rijnvliet. UTRECHT | 15 - 17 |
| 2022-03-06 | 14:30 | The Pickwick Players 1 | RC The Dukes Espoirs | Sportpark Keizerslanden. DEVENTER | 0 - 27 |
| 2022-03-06 | 15:00 | RC Eemland 2 | RC The Bassets 2 | Sportpark De Bokkeduinen. AMERSFOORT | 67 - 17 |
| 2022-03-13 | 14:30 | URC 2 | RC Eemland 2 | Sportpark Rijnvliet. UTRECHT | 10 - 45 |
| 2022-03-13 | 15:00 | RC The Dukes Espoirs | RC The Bassets 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 64 - 17 |
| 2022-03-13 | 15:00 | RC Hilversum 2 | The Pickwick Players 1 | Sportpark Berestein. Hilversum | 17 - 20 |
| 2022-03-20 | 14:30 | The Pickwick Players 1 | URC 2 | Sportpark Keizerslanden. DEVENTER | 9 - 7 |
| 2022-03-20 | 14:30 | RC The Bassets 2 | RC Hilversum 2 | SASSENHEIM | 8 - 65 |
| 2022-03-20 | 15:00 | RC The Dukes Espoirs | RC Eemland 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 24 - 10 |
| 2022-04-03 | 14:45 | URC 2 | RC The Bassets 2 | Sportpark Rijnvliet. UTRECHT | 33 - 0 |
| 2022-04-03 | 15:00 | RC Hilversum 2 | RC The Dukes Espoirs | Sportpark Berestein. Hilversum | 15 - 15 |
| 2022-04-03 | 15:00 | RC Eemland 2 | The Pickwick Players 1 | Sportpark De Bokkeduinen. AMERSFOORT | 24 - 0 |
| 2022-04-10 | 14:30 | The Pickwick Players 1 | RC The Bassets 2 | Sportpark Keizerslanden. DEVENTER | 66 - 0 |
| 2022-04-10 | 15:00 | RC Eemland 2 | RC Hilversum 2 | Sportpark De Bokkeduinen. AMERSFOORT | 18 - 19 |
| 2022-04-10 | 15:00 | RC The Dukes Espoirs | URC 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 45 - 17 |
| 2022-04-24 | 12:30 | RC The Bassets 2 | RC Eemland 2 | SASSENHEIM | 5 - 29 |
| 2022-04-24 | 15:00 | RC The Dukes Espoirs | The Pickwick Players 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 36 - 3 |
| 2022-04-24 | 15:00 | RC Hilversum 2 | URC 2 | Sportpark Berestein. Hilversum | 33 - 29 |
| 2022-05-15 | 12:30 | RC The Bassets 2 | RC The Dukes Espoirs | SASSENHEIM | 20 - 44 |
| 2022-05-15 | 14:30 | The Pickwick Players 1 | RC Hilversum 2 | Sportpark Keizerslanden. DEVENTER | 25 - 24 |
| 2022-05-15 | 15:00 | RC Eemland 2 | URC 2 | Sportpark De Bokkeduinen. AMERSFOORT | 30 - 0 |
| 2022-05-22 | 14:30 | URC 2 | The Pickwick Players 1 | Sportpark Rijnvliet. UTRECHT | 0 - 30 |
| 2022-05-22 | 15:00 | RC Hilversum 2 | RC The Bassets 2 | Sportpark Berestein. Hilversum | 30 - 0 |
| 2022-05-22 | 15:00 | RC Eemland 2 | RC The Dukes Espoirs | Sportpark De Bokkeduinen. AMERSFOORT | 34 - 24 |
| 2022-05-29 | 14:30 | RC The Bassets 2 | URC 2 | SASSENHEIM | 41 - 24 |
| 2022-05-29 | 14:30 | The Pickwick Players 1 | RC Eemland 2 | Sportpark Keizerslanden. DEVENTER | 8 - 55 |
| 2022-05-29 | 15:00 | RC The Dukes Espoirs | RC Hilversum 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 22 - 22 |