| 2022-02-20 | 14:30 | RFC The Rams 1 | ERC '69 1 | Marialust. APELDOORN | 30 - 0 |
| 2022-02-20 | 14:30 | RC the Pink Panthers 1 | RC Groningen 2 | De Woerd. DRIEBERGEN | 5 - 24 |
| 2022-02-27 | 14:00 | Zaandijk Rugby 1 | Amstelveense RC 2 | SPORTPARK JAGERSVELD. ZAANDAM | 36 - 12 |
| 2022-03-06 | 15:00 | ERC '69 1 | RC the Pink Panthers 1 | Wethouder Horstman Sportpark. ENSCHEDE | 49 - 12 |
| 2022-03-06 | 15:00 | Amstelveense RC 2 | RFC The Rams 1 | Sportpark Sportlaan West. AMSTELVEEN | 34 - 19 |
| 2022-03-06 | 15:00 | RC Groningen 2 | Zaandijk Rugby 1 | Esserberg. HAREN | 24 - 27 |
| 2022-03-13 | 14:30 | RFC The Rams 1 | Zaandijk Rugby 1 | Marialust. APELDOORN | 15 - 22 |
| 2022-03-13 | 14:30 | RC the Pink Panthers 1 | Amstelveense RC 2 | De Woerd. DRIEBERGEN | 29 - 25 |
| 2022-03-13 | 15:00 | ERC '69 1 | RC Groningen 2 | Wethouder Horstman Sportpark. ENSCHEDE | 48 - 5 |
| 2022-03-20 | 14:00 | Zaandijk Rugby 1 | RC the Pink Panthers 1 | SPORTPARK JAGERSVELD. ZAANDAM | 52 - 7 |
| 2022-03-20 | 14:30 | RFC The Rams 1 | RC Groningen 2 | Marialust. APELDOORN | 14 - 17 |
| 2022-03-20 | 15:00 | Amstelveense RC 2 | ERC '69 1 | Sportpark Sportlaan West. AMSTELVEEN | 45 - 21 |
| 2022-04-03 | 14:30 | RC the Pink Panthers 1 | RFC The Rams 1 | De Woerd. DRIEBERGEN | 20 - 18 |
| 2022-04-03 | 15:00 | ERC '69 1 | Zaandijk Rugby 1 | Wethouder Horstman Sportpark. ENSCHEDE | 26 - 19 |
| 2022-04-03 | 15:00 | RC Groningen 2 | Amstelveense RC 2 | Esserberg. HAREN | 52 - 21 |
| 2022-04-10 | 14:30 | RFC The Rams 1 | ERC '69 1 | Marialust. APELDOORN | 46 - 19 |
| 2022-04-10 | 15:00 | Amstelveense RC 2 | Zaandijk Rugby 1 | Sportpark Sportlaan West. AMSTELVEEN | 37 - 38 |
| 2022-04-10 | 15:00 | RC Groningen 2 | RC the Pink Panthers 1 | Esserberg. HAREN | 45 - 12 |
| 2022-04-24 | 14:00 | Zaandijk Rugby 1 | RC Groningen 2 | SPORTPARK JAGERSVELD. ZAANDAM | 36 - 0 |
| 2022-04-24 | 14:30 | RC the Pink Panthers 1 | ERC '69 1 | De Woerd. DRIEBERGEN | 40 - 31 |
| 2022-04-24 | 14:30 | RFC The Rams 1 | Amstelveense RC 2 | Marialust. APELDOORN | 24 - 14 |
| 2022-05-15 | 14:00 | Zaandijk Rugby 1 | RFC The Rams 1 | SPORTPARK JAGERSVELD. ZAANDAM | 24 - 57 |
| 2022-05-15 | 15:00 | Amstelveense RC 2 | RC the Pink Panthers 1 | Sportpark Sportlaan West. AMSTELVEEN | 79 - 0 |
| 2022-05-15 | 15:00 | RC Groningen 2 | ERC '69 1 | Esserberg. HAREN | 17 - 44 |
| 2022-05-22 | 13:00 | RC the Pink Panthers 1 | Zaandijk Rugby 1 | De Woerd. DRIEBERGEN | 12 - 36 |
| 2022-05-22 | 15:00 | RC Groningen 2 | RFC The Rams 1 | Esserberg. HAREN | 12 - 40 |
| 2022-05-22 | 15:00 | ERC '69 1 | Amstelveense RC 2 | Wethouder Horstman Sportpark. ENSCHEDE | 0 - 67 |
| 2022-05-29 | 14:00 | Zaandijk Rugby 1 | ERC '69 1 | SPORTPARK JAGERSVELD. ZAANDAM | 17 - 26 |
| 2022-05-29 | 14:30 | RFC The Rams 1 | RC the Pink Panthers 1 | Marialust. APELDOORN | 99 - 12 |
| 2022-05-29 | 15:00 | Amstelveense RC 2 | RC Groningen 2 | Sportpark Sportlaan West. AMSTELVEEN | 90 - 0 |