| 2022-02-20 | 14:00 | DRC The Wild Rovers 1 | RC The Big Bulls 1 | Sportpark de Bezelhorst. DOETINCHEM | 38 - 14 |
| 2022-02-20 | 14:00 | Feanster Rugby Club 1 | RC De Betuwe 1 | Sportpark Buitenbaan. HEERENVEEN | 81 - 0 |
| 2022-02-20 | 15:00 | G.S.R.C. 1 | RC Dwingeloo 1 | GRONINGEN | 0 - 30 |
| 2022-03-06 | 13:30 | RC De Betuwe 1 | G.S.R.C. 1 | Sportpark De Heister. BEMMEL | 5 - 24 |
| 2022-03-06 | 14:30 | RC Dwingeloo 1 | DRC The Wild Rovers 1 | Sportpark De Hulsebosch. DWINGELOO | 30 - 0 |
| 2022-03-06 | 14:30 | RC The Big Bulls 1 | Feanster Rugby Club 1 | Het Wendelgoor. Almelo | 0 - 63 |
| 2022-03-13 | 14:00 | DRC The Wild Rovers 1 | RC De Betuwe 1 | Sportpark de Bezelhorst. DOETINCHEM | 62 - 26 |
| 2022-03-13 | 14:30 | RC Dwingeloo 1 | RC The Big Bulls 1 | Sportpark De Hulsebosch. DWINGELOO | 40 - 27 |
| 2022-03-13 | 15:00 | G.S.R.C. 1 | Feanster Rugby Club 1 | GRONINGEN | 17 - 38 |
| 2022-03-20 | 13:30 | RC De Betuwe 1 | RC Dwingeloo 1 | Sportpark De Heister. BEMMEL | 31 - 54 |
| 2022-03-20 | 14:00 | Feanster Rugby Club 1 | DRC The Wild Rovers 1 | Sportpark Buitenbaan. HEERENVEEN | 153 - 7 |
| 2022-03-20 | 15:00 | G.S.R.C. 1 | RC The Big Bulls 1 | GRONINGEN | 38 - 12 |
| 2022-04-03 | 14:00 | DRC The Wild Rovers 1 | G.S.R.C. 1 | Sportpark de Bezelhorst. DOETINCHEM | 41 - 14 |
| 2022-04-03 | 14:30 | RC Dwingeloo 1 | Feanster Rugby Club 1 | Sportpark De Hulsebosch. DWINGELOO | 24 - 59 |
| 2022-04-03 | 14:30 | RC The Big Bulls 1 | RC De Betuwe 1 | Het Wendelgoor. Almelo | 56 - 14 |
| 2022-04-10 | 13:00 | RC Dwingeloo 1 | G.S.R.C. 1 | Sportpark De Hulsebosch. DWINGELOO | 34 - 41 |
| 2022-04-10 | 13:30 | RC De Betuwe 1 | Feanster Rugby Club 1 | Sportpark De Heister. BEMMEL | 21 - 26 |
| 2022-04-10 | 14:30 | RC The Big Bulls 1 | DRC The Wild Rovers 1 | Het Wendelgoor. Almelo | 61 - 31 |
| 2022-04-24 | 13:30 | G.S.R.C. 1 | RC De Betuwe 1 | GRONINGEN | 31 - 12 |
| 2022-04-24 | 14:00 | Feanster Rugby Club 1 | RC The Big Bulls 1 | Sportpark Buitenbaan. HEERENVEEN | 30 - 0 |
| 2022-04-24 | 14:30 | RC Dwingeloo 1 | DRC The Wild Rovers 1 | Sportpark De Hulsebosch. DWINGELOO | 52 - 21 |
| 2022-05-08 | 14:30 | RC The Big Bulls 1 | G.S.R.C. 1 | Het Wendelgoor. Almelo | 12 - 28 |
| 2022-05-15 | 13:30 | RC De Betuwe 1 | DRC The Wild Rovers 1 | Sportpark De Heister. BEMMEL | 64 - 43 |
| 2022-05-15 | 14:00 | Feanster Rugby Club 1 | G.S.R.C. 1 | Sportpark Buitenbaan. HEERENVEEN | 78 - 3 |
| 2022-05-15 | 14:30 | RC The Big Bulls 1 | RC Dwingeloo 1 | Het Wendelgoor. Almelo | 26 - 34 |
| 2022-05-22 | 13:00 | RC Dwingeloo 1 | RC De Betuwe 1 | Sportpark De Hulsebosch. DWINGELOO | 76 - 3 |
| 2022-05-22 | 14:00 | DRC The Wild Rovers 1 | Feanster Rugby Club 1 | Sportpark de Bezelhorst. DOETINCHEM | 7 - 82 |
| 2022-05-29 | 13:00 | G.S.R.C. 1 | DRC The Wild Rovers 1 | GRONINGEN | 68 - 12 |
| 2022-05-29 | 13:30 | RC De Betuwe 1 | RC The Big Bulls 1 | Sportpark De Heister. BEMMEL | 50 - 14 |
| 2022-05-29 | 14:00 | Feanster Rugby Club 1 | RC Dwingeloo 1 | Sportpark Buitenbaan. HEERENVEEN | 30 - 0 |