| 2022-02-20 | 14:00 | CL Harlequins/Dragons 1 | ARC The Pigs 1 | Sportpark de Thij. Oldenzaal | 46 - 7 |
| 2022-02-27 | 15:00 | RC The Big Stones 1 | RC Wageningen 1 | Evenemententerrein. HAVELTE | 30 - 0 |
| 2022-03-06 | 13:00 | RC Wageningen 1 | CL Harlequins/Dragons 1 | Sportpark De Zoom. WAGENINGEN | 7 - 73 |
| 2022-03-06 | 14:30 | ARC The Pigs 1 | Rugby Club Greate Pier 1 | Sportpark De Bakenhof. ARNHEM | 29 - 26 |
| 2022-03-13 | 13:00 | Rugby Club Greate Pier 1 | RC Wageningen 1 | De Arumer Velden. LEEUWARDEN | 83 - 5 |
| 2022-03-13 | 14:00 | CL Harlequins/Dragons 1 | RC The Big Stones 1 | Sportpark Veldwijk. HENGELO OV | 62 - 12 |
| 2022-03-20 | 14:00 | RC The Big Stones 1 | Rugby Club Greate Pier 1 | Evenemententerrein. HAVELTE | 41 - 14 |
| 2022-03-20 | 14:30 | RC Wageningen 1 | ARC The Pigs 1 | Sportpark De Zoom. WAGENINGEN | 54 - 17 |
| 2022-04-03 | 14:00 | Rugby Club Greate Pier 1 | CL Harlequins/Dragons 1 | De Arumer Velden. LEEUWARDEN | 17 - 31 |
| 2022-04-03 | 14:30 | ARC The Pigs 1 | RC The Big Stones 1 | Sportpark De Bakenhof. ARNHEM | 47 - 19 |
| 2022-04-10 | 14:00 | RC The Big Stones 1 | RC Wageningen 1 | Evenemententerrein. HAVELTE | 31 - 15 |
| 2022-04-24 | 14:00 | CL Harlequins/Dragons 1 | RC Wageningen 1 | Sportpark Veldwijk. HENGELO OV | 31 - 19 |
| 2022-04-24 | 14:00 | Rugby Club Greate Pier 1 | ARC The Pigs 1 | De Arumer Velden. LEEUWARDEN | 47 - 26 |
| 2022-05-08 | 14:30 | ARC The Pigs 1 | CL Harlequins/Dragons 1 | Sportpark De Bakenhof. ARNHEM | 40 - 19 |
| 2022-05-15 | 13:00 | RC The Big Stones 1 | CL Harlequins/Dragons 1 | Evenemententerrein. HAVELTE | 17 - 33 |
| 2022-05-15 | 15:00 | RC Wageningen 1 | Rugby Club Greate Pier 1 | Sportpark De Zoom. WAGENINGEN | 5 - 57 |
| 2022-05-22 | 14:30 | ARC The Pigs 1 | RC Wageningen 1 | Sportpark De Bakenhof. ARNHEM | 17 - 19 |
| 2022-05-22 | 15:00 | Rugby Club Greate Pier 1 | RC The Big Stones 1 | De Arumer Velden. LEEUWARDEN | 62 - 5 |
| 2022-05-29 | 13:00 | CL Harlequins/Dragons 1 | Rugby Club Greate Pier 1 | Sportpark de Thij. Oldenzaal | 89 - 28 |
| 2022-05-29 | 14:00 | RC The Big Stones 1 | ARC The Pigs 1 | Evenemententerrein. HAVELTE | 12 - 36 |