| 2022-02-20 | 15:00 | TSRC Tarantula 1 | VRC The Vets 1 | Rugbyvelden RC Tilburg. Tilburg | 26 - 36 |
| 2022-02-27 | 14:30 | The Hague Hornets 1 | URC 3 | Sportcomplex Beresteinlaan. Den Haag | 17 - 34 |
| 2022-03-06 | 13:00 | VRC The Vets 1 | The Elephants 1 | Sportpark Den Dries. VALKENSWAARD | 52 - 7 |
| 2022-03-06 | 13:00 | RC Nieuwegein 1 | The Hague Hornets 1 | Sportpark Galecop. NIEUWEGEIN | 12 - 31 |
| 2022-03-13 | 13:00 | URC 3 | VRC The Vets 1 | Sportpark Rijnvliet. UTRECHT | 64 - 12 |
| 2022-03-13 | 13:00 | The Hague Hornets 1 | The Elephants 1 | Sportcomplex Beresteinlaan. Den Haag | 35 - 18 |
| 2022-03-13 | 15:00 | TSRC Tarantula 1 | RC Nieuwegein 1 | Rugbyvelden RC Tilburg. Tilburg | 87 - 14 |
| 2022-03-20 | 13:00 | RC Nieuwegein 1 | URC 3 | Sportpark Galecop. NIEUWEGEIN | 0 - 52 |
| 2022-03-20 | 13:00 | The Elephants 1 | TSRC Tarantula 1 | Eindhoven Noord. EINDHOVEN | 35 - 26 |
| 2022-03-20 | 14:30 | The Hague Hornets 1 | VRC The Vets 1 | Sportcomplex Beresteinlaan. Den Haag | 7 - 34 |
| 2022-03-27 | 13:00 | URC 3 | TSRC Tarantula 1 | Sportpark Rijnvliet. UTRECHT | 19 - 7 |
| 2022-03-27 | 15:00 | The Elephants 1 | RC Nieuwegein 1 | Eindhoven Noord. EINDHOVEN | 30 - 0 |
| 2022-04-03 | 13:00 | URC 3 | The Elephants 1 | Sportpark Rijnvliet. UTRECHT | 32 - 36 |
| 2022-04-03 | 13:00 | VRC The Vets 1 | RC Nieuwegein 1 | Sportpark Den Dries. VALKENSWAARD | 94 - 20 |
| 2022-04-10 | 13:00 | URC 3 | The Hague Hornets 1 | Sportpark Rijnvliet. UTRECHT | 38 - 36 |
| 2022-04-10 | 15:00 | The Elephants 1 | RC Nieuwegein 1 | Eindhoven Noord. EINDHOVEN | 68 - 10 |
| 2022-04-24 | 13:00 | The Elephants 1 | VRC The Vets 1 | Eindhoven Noord. EINDHOVEN | 59 - 21 |
| 2022-04-24 | 14:30 | The Hague Hornets 1 | RC Nieuwegein 1 | Sportcomplex Beresteinlaan. Den Haag | 72 - 5 |
| 2022-04-24 | 15:00 | TSRC Tarantula 1 | URC 3 | Rugbyvelden RC Tilburg. Tilburg | 40 - 0 |
| 2022-05-01 | 13:00 | VRC The Vets 1 | TSRC Tarantula 1 | Sportpark Den Dries. VALKENSWAARD | 10 - 33 |
| 2022-05-01 | 15:00 | The Elephants 1 | URC 3 | Eindhoven Noord. EINDHOVEN | 43 - 5 |
| 2022-05-08 | 15:00 | TSRC Tarantula 1 | The Hague Hornets 1 | Rugbyvelden RC Tilburg. Tilburg | 7 - 43 |
| 2022-05-15 | 11:30 | The Elephants 1 | The Hague Hornets 1 | Eindhoven Noord. EINDHOVEN | 22 - 48 |
| 2022-05-15 | 13:00 | RC Nieuwegein 1 | TSRC Tarantula 1 | Sportpark Galecop. NIEUWEGEIN | 17 - 62 |
| 2022-05-15 | 13:00 | VRC The Vets 1 | URC 3 | Sportpark Den Dries. VALKENSWAARD | 59 - 26 |
| 2022-05-22 | 11:30 | URC 3 | RC Nieuwegein 1 | Sportpark Rijnvliet. UTRECHT | 67 - 14 |
| 2022-05-22 | 13:00 | VRC The Vets 1 | The Hague Hornets 1 | Sportpark Den Dries. VALKENSWAARD | 5 - 61 |
| 2022-05-22 | 16:00 | TSRC Tarantula 1 | The Elephants 1 | Rugbyvelden RC Tilburg. Tilburg | 12 - 38 |
| 2022-05-29 | 13:00 | RC Nieuwegein 1 | VRC The Vets 1 | Sportpark Galecop. NIEUWEGEIN | 64 - 59 |
| 2022-05-29 | 14:30 | The Hague Hornets 1 | TSRC Tarantula 1 | Sportcomplex Beresteinlaan. Den Haag | 30 - 0 |