| 2022-02-20 | 14:00 | RC Drachten 1 | RC Zwolle 2 | it Dwarsfjild. DRACHTEN | 9 - 0 |
| 2022-02-20 | 15:00 | RC Sneek 1 | DRC Phoenix 1 | Schuttersveld. Sneek | 46 - 12 |
| 2022-02-27 | 13:00 | CL Pickwick Players/Rams 2 | ERC '69 2 | Marialust. APELDOORN | 39 - 21 |
| 2022-03-06 | 13:00 | RC Zwolle 2 | CL Pickwick Players/Rams 2 | Sportpark De Marslanden. ZWOLLE | 56 - 5 |
| 2022-03-06 | 13:00 | ERC '69 2 | RC Sneek 1 | Wethouder Horstman Sportpark. ENSCHEDE | 12 - 62 |
| 2022-03-06 | 15:00 | DRC Phoenix 1 | RC Drachten 1 | Sportpark Tuikwerd. DELFZIJL | 24 - 44 |
| 2022-03-13 | 14:00 | DRC Phoenix 1 | RC Zwolle 2 | Sportpark Tuikwerd. DELFZIJL | 0 - 30 |
| 2022-03-13 | 15:00 | RC Sneek 1 | CL Pickwick Players/Rams 2 | Schuttersveld. Sneek | 87 - 19 |
| 2022-03-20 | 13:00 | CL Pickwick Players/Rams 2 | RC Drachten 1 | Sportpark Keizerslanden. DEVENTER | 7 - 19 |
| 2022-03-20 | 15:00 | RC Sneek 1 | RC Zwolle 2 | Schuttersveld. Sneek | 12 - 22 |
| 2022-03-20 | 15:00 | ERC '69 2 | DRC Phoenix 1 | Wethouder Horstman Sportpark. ENSCHEDE | 43 - 21 |
| 2022-03-27 | 14:00 | RC Drachten 1 | ERC '69 2 | it Dwarsfjild. DRACHTEN | 94 - 31 |
| 2022-04-03 | 12:00 | RC Zwolle 2 | ERC '69 2 | Sportpark De Marslanden. ZWOLLE | 95 - 0 |
| 2022-04-03 | 14:00 | RC Drachten 1 | RC Sneek 1 | it Dwarsfjild. DRACHTEN | 66 - 7 |
| 2022-04-10 | 13:00 | ERC '69 2 | CL Pickwick Players/Rams 2 | Wethouder Horstman Sportpark. ENSCHEDE | 5 - 43 |
| 2022-04-10 | 14:00 | DRC Phoenix 1 | RC Sneek 1 | Sportpark Tuikwerd. DELFZIJL | 50 - 49 |
| 2022-04-24 | 13:00 | CL Pickwick Players/Rams 2 | RC Zwolle 2 | Marialust. APELDOORN | 14 - 62 |
| 2022-04-24 | 14:00 | RC Drachten 1 | DRC Phoenix 1 | it Dwarsfjild. DRACHTEN | 77 - 19 |
| 2022-04-24 | 15:00 | RC Sneek 1 | ERC '69 2 | Schuttersveld. Sneek | 30 - 0 |
| 2022-05-08 | 14:00 | DRC Phoenix 1 | CL Pickwick Players/Rams 2 | Sportpark Tuikwerd. DELFZIJL | 34 - 27 |
| 2022-05-08 | 15:00 | RC Drachten 1 | RC Zwolle 2 | it Dwarsfjild. DRACHTEN | 0 - 60 |
| 2022-05-15 | 13:00 | CL Pickwick Players/Rams 2 | RC Sneek 1 | Sportpark Keizerslanden. DEVENTER | 48 - 28 |
| 2022-05-15 | 13:00 | RC Zwolle 2 | DRC Phoenix 1 | Sportpark De Marslanden. ZWOLLE | 30 - 0 |
| 2022-05-15 | 15:00 | ERC '69 2 | RC Drachten 1 | Wethouder Horstman Sportpark. ENSCHEDE | 14 - 101 |
| 2022-05-22 | 12:00 | RC Zwolle 2 | RC Sneek 1 | Sportpark De Marslanden. ZWOLLE | 59 - 21 |
| 2022-05-22 | 13:00 | DRC Phoenix 1 | ERC '69 2 | Sportpark Tuikwerd. DELFZIJL | 83 - 15 |
| 2022-05-22 | 15:00 | RC Drachten 1 | CL Pickwick Players/Rams 2 | it Dwarsfjild. DRACHTEN | 64 - 14 |
| 2022-05-29 | 13:00 | CL Pickwick Players/Rams 2 | DRC Phoenix 1 | Apeldoorn | 30 - 0 |
| 2022-05-29 | 13:00 | ERC '69 2 | RC Zwolle 2 | Wethouder Horstman Sportpark. ENSCHEDE | 3 - 86 |
| 2022-05-29 | 15:00 | RC Sneek 1 | RC Drachten 1 | Schuttersveld. Sneek | 26 - 40 |