| 2022-02-20 | 11:00 | RC The Dukes 4 | RC Octopus 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 38 - 22 |
| 2022-02-20 | 14:00 | CL R.E.D. 1 | Bredase RC 3 | Sportpark Schenkeldijk. DORDRECHT | 0 - 47 |
| 2022-03-13 | 11:00 | RC The Dukes 4 | CL R.E.D. 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 78 - 12 |
| 2022-03-20 | 12:00 | Bredase RC 3 | RC Octopus 2 | Sportboulevard Wisselaar. BREDA | 46 - 19 |
| 2022-03-27 | 11:00 | Bredase RC 3 | RC The Dukes 4 | Sportboulevard Wisselaar. BREDA | 19 - 25 |
| 2022-03-27 | 12:00 | RC Octopus 2 | RC Aachen 2 | Moleneind. Uden | 31 - 12 |
| 2022-04-03 | 00:00 | RC Octopus 2 | CL R.E.D. 1 | Moleneind. Uden | geschrapt |
| 2022-04-10 | 00:00 | Bredase RC 3 | CL R.E.D. 1 | Sportboulevard Wisselaar. BREDA | geschrapt |
| 2022-04-10 | 12:00 | RC Octopus 2 | RC The Dukes 4 | Moleneind. Uden | 5 - 27 |
| 2022-04-24 | 11:00 | RC The Dukes 4 | Bredase RC 3 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 69 - 42 |
| 2022-04-24 | 14:00 | RC Aachen 2 | RC Octopus 2 | Schulenzentrum Handerweg. Aachen | 30 - 0 |
| 2022-05-01 | 00:00 | CL R.E.D. 1 | RC Aachen 2 | Sportpark Schenkeldijk. DORDRECHT | geschrapt |
| 2022-05-01 | 13:00 | RC Aachen 2 | RC The Dukes 4 | Schulenzentrum Handerweg. Aachen | 0 - 27 |
| 2022-05-08 | 14:30 | RC Aachen 2 | Bredase RC 3 | Schulenzentrum Handerweg. Aachen | 22 - 12 |
| 2022-05-14 | 15:00 | Bredase RC 3 | RC Aachen 2 | Sportboulevard Wisselaar. BREDA | 26 - 26 |
| 2022-05-15 | 00:00 | CL R.E.D. 1 | RC The Dukes 4 | Sportpark Schenkeldijk. DORDRECHT | geschrapt |
| 2022-05-22 | 00:00 | RC Aachen 2 | CL R.E.D. 1 | Schulenzentrum Handerweg. Aachen | geschrapt |
| 2022-05-22 | 12:30 | RC Octopus 2 | Bredase RC 3 | Moleneind. Uden | 0 - 14 |
| 2022-05-29 | 00:00 | CL R.E.D. 1 | RC Octopus 2 | Sportpark Schenkeldijk. DORDRECHT | geschrapt |
| 2022-05-29 | 11:00 | RC The Dukes 4 | RC Aachen 2 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 15 - 19 |