| 2022-03-26 | 15:00 | RC DIOK 1 | RC 't Gooi 1 | RC DIOK. LEIDEN | 22 - 15 |
| 2022-03-26 | 15:00 | Cas RC 1 | RC The Dukes 1 | Sportpark Wouterland. CASTRICUM | 13 - 18 |
| 2022-03-26 | 15:00 | RFC Haarlem 1 | Haagsche RC 1 | Van der Aart Sportpark. HAARLEM | 55 - 7 |
| 2022-03-26 | 15:00 | RC Eemland 1 | RC Hilversum 1 | Sportpark De Bokkeduinen. AMERSFOORT | 26 - 26 |
| 2022-04-02 | 15:00 | RC The Dukes 1 | RC Eemland 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 31 - 32 |
| 2022-04-02 | 15:00 | RC Hilversum 1 | RC DIOK 1 | Sportpark Berestein. Hilversum | 13 - 31 |
| 2022-04-02 | 16:00 | Haagsche RC 1 | Cas RC 1 | Haagsche Rugby Club. DEN HAAG | 17 - 45 |
| 2022-04-02 | 16:00 | RC 't Gooi 1 | RFC Haarlem 1 | Sportpark. NAARDEN | 17 - 8 |
| 2022-04-09 | 14:00 | RFC Haarlem 1 | RC Hilversum 1 | Van der Aart Sportpark. HAARLEM | 23 - 19 |
| 2022-04-09 | 15:00 | Cas RC 1 | RC 't Gooi 1 | Sportpark Wouterland. CASTRICUM | 27 - 28 |
| 2022-04-09 | 16:00 | Haagsche RC 1 | RC The Dukes 1 | Haagsche Rugby Club. DEN HAAG | 10 - 25 |
| 2022-04-23 | 15:00 | RC The Dukes 1 | RC DIOK 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 28 - 26 |
| 2022-04-23 | 15:00 | RC Hilversum 1 | Cas RC 1 | Sportpark Berestein. Hilversum | 24 - 30 |
| 2022-04-23 | 15:00 | RC Eemland 1 | RFC Haarlem 1 | Sportpark De Bokkeduinen. AMERSFOORT | 19 - 60 |
| 2022-04-23 | 15:00 | RC 't Gooi 1 | Haagsche RC 1 | Sportpark. NAARDEN | 19 - 22 |
| 2022-04-30 | 15:00 | RFC Haarlem 1 | RC DIOK 1 | Van der Aart Sportpark. HAARLEM | 17 - 33 |
| 2022-04-30 | 15:00 | RC 't Gooi 1 | RC The Dukes 1 | Sportpark. NAARDEN | 22 - 0 |
| 2022-04-30 | 15:00 | RC Eemland 1 | Cas RC 1 | Sportpark De Bokkeduinen. AMERSFOORT | 28 - 25 |
| 2022-04-30 | 16:00 | Haagsche RC 1 | RC Hilversum 1 | Haagsche Rugby Club. DEN HAAG | 40 - 32 |
| 2022-05-07 | 15:00 | RC DIOK 1 | RC Eemland 1 | RC DIOK. LEIDEN | 31 - 22 |
| 2022-05-14 | 15:00 | RC 't Gooi 1 | RC Hilversum 1 | Sportpark. NAARDEN | 22 - 28 |
| 2022-05-14 | 15:00 | RC The Dukes 1 | RFC Haarlem 1 | RUGBYCLUB THE DUKES. 'S - HERTOGENBOSCH | 28 - 29 |
| 2022-05-14 | 15:00 | Cas RC 1 | RC DIOK 1 | Sportpark Wouterland. CASTRICUM | 21 - 17 |
| 2022-05-14 | 16:00 | Haagsche RC 1 | RC Eemland 1 | Haagsche Rugby Club. DEN HAAG | 21 - 23 |
| 2022-05-21 | 15:00 | RC Hilversum 1 | RC The Dukes 1 | Sportpark Berestein. Hilversum | 14 - 36 |
| 2022-05-21 | 15:00 | RC DIOK 1 | Haagsche RC 1 | RC DIOK. LEIDEN | 45 - 25 |
| 2022-05-21 | 15:00 | RC Eemland 1 | RC 't Gooi 1 | Sportpark De Bokkeduinen. AMERSFOORT | 19 - 25 |
| 2022-05-21 | 15:00 | RFC Haarlem 1 | Cas RC 1 | Van der Aart Sportpark. HAARLEM | 31 - 14 |